HRT 4 ALL / Blockers Guide
The guide for practicing safe DIY Hormonal Treatment
Made by teens for teens
We have a Matrix Server, it's similar to Discord. Please join for support, DIY Safely!
Puberty Blockers
are medicines used to postpone or suppress natal puberty in children.
If you've already started or about to undergo puberty,
puberty blockers can be used to halt it to stop any further bodily changes like masculinization or feminization.
This can be taken instead of sex hormones like estrogen or testosterone, just in case you need more time to think about transitioning.
However puberty blockers should only be used in individuals who haven't completed puberty, known also as Tanner 5.
I recommend for all those planning to pratice DIY to learn about tanner stages.
Click the links below to learn more.
All the effects that puberty blockers showcase are reversible. For example, when you postpone your puberty with blockers you can simply get off of it and resume your puberty. You'll continue growing and developing as you would've if you weren't on it in the first place. Of course, if you choose to take sex hormones like estrogen or testosterone you're body will develop differently.
Currently working on this section of the article, about one to two weeks for completion. This requires a lot of research that I've yet to do.
The only viable available option for blocking puberty in Trans Males is a medicine called Relugolix. Relugolix is a GNRH Antagonist, it works by blocking the hormones that stimulates the production of estrogen and testosterone. Within 24 Hours of it's consumption it suppresses estrogen to postmenopausal levels, halting puberty.
Currently there is only one retailer of Relugolix, you'll purchase from them using their eCommerce store.
Note: If you're planning on purchasing Relugolix, I would recommend also purchasing a pill cutter to cut the pills into 20mg.
Consider this a good thing, because if you buy a pack of 100 Pills, each being 40mg. That means it could last you 200 days or more!
The guide on how to purchase Bitcoin/Crypto is rather long, so I decided to make a separate page here.
For trans girls there are many viable choices when it comes to puberty blockers.
The primary selection of blockers I'll be focusing on are called Anti-Androgens.
Anti-androgens also known as anti-testosterones or testosterone blockers,
are used as puberty blockers since they block or suppress testosterone which stops male puberty.
For anti-androgens, you can use the following 3 medicines.
Bicalutamide, Cyproterone Acetate or Spironolactone.
Heads up, this is going kinda deep into mechanism of action so this may be confusing to you.
Cyproterone
is an anti-androgen that stops the production of testosterone so you no longer masculinize.
The primary benefits root from the anti-androgenic effects where testosterone and
dihydrotestosterone (DHT)
are directly blocked from being produced in the gonads (testicles) and while partially, from interacting with the androgen receptors.
For the anti-gonadotropic effects which also help reduce testosterone production, Cyproterone
inhibits the release of LH.
The Gonadotropin purposed for interacting with the Leydig Cells, which produce testosterone.
So not only does the testosterone in your body decrease, it also prevents the testosterone from producing any effects.
Cyproterone is the most recommended anti-androgen, despite being 2nd most effective on this list.
We recommend Cyproterone because it's an affordable,
potent anti-androgen that isn't a
Selective Androgen Receptor Modulator (SARM)
unlike Bicalutamide
Bicalutamide
is an anti-androgen that stops the effects of testosterone.
It doesn't stop the production of it, but it stops the effects.
So you won't masculinize but you'll still have male ranges of testosterone in your body.
This is because Bicalutamide is a SARM
that works by selectively inhibiting testosterones from interacting with the androgen receptors.
Bicalutamide is the 2nd most recommended anti-androgen,
though a more effective and potent anti-androgen than Cyproterone.
We rank Bicalutamide at 2nd due to it being expensive and untestable if you get
blood tests done albeit widely available.
At the end of the day, it does it's job as an anti-androgen.
Spironolactone
is a weak anti-androgen that stops the production of testosterone.
It's more likely to produce better effects in early tanner-stage trans girls.
This is because in younger girls their testes aren't as fully developed,
thus their body doesn't produce as much testosterone.
The biggest and only pro about Spironolactone is that it's low-risk in terms of adverse effects.
Spironolactone is the 3rd most recommended anti-androgen and the 3rd most effective,
because of it's low effectiveness and high interindividual variability.
It's slightly expensive but if you can, buy Cyproterone or Bicalutamide.
There's no reason to buy Spironolactone if you can buy the other two.
I made a list of anti-androgens you could purchase to preform the role of puberty blockers.
Please checkout these HRT lists, they provide several updated sources to anti-androgens and more.
DiyHrt Market
HRT Cafe
Cyproterone Note:
If you already took a peak at the dosages below,
you may have noticed the Cyproterone concentration in each pill is about 4-8x times higher than your age recommended dosage.
This is because Cyproterone actually only needs about 5mg to 10mg per day to be effective in suppressing testosterone.
Way lower than the provided dose in each pill...
So if you're planning on purchasing Cyproterone, I would recommend also purchasing a pill cutter to cut the pills into smaller doses.
Consider this a good thing, because if you buy a pack of 50 Pills, each being 50mg. That means it could last you 200 days or more!
The guide on how to purchase Bitcoin/Crypto is rather long, so I decided to make a separate page here.
In this segment I'll be discussing puberty blocker dosages respective to individuals' age. The goal for taking puberty blockers is to suppress the sex hormones in your body, to avoid going through or finishing puberty. If you buy any other formulation of puberty blockers or anti-androgens, please message me on Signal or join the Matrix Server so I can provide guidance.
There is no hormone dosage recommendation for transgender kids for those 11 years old and younger.
I cannot safely guarantee any form of safe HRT administration within minors of this age range.
Please do not practice DIY HRT if you are 11 years old or under.
Contact your primary doctor about Puberty Blockers if you wish to stop future and present masculinization. This option is best recommended for those who live in transgender-tolerant countries or Democratic states.
Unfortunately if you live in anti-transgender countries or Republican states.
You will most likely be prohibited from receiving any hormonal treatment or puberty blockers due to state laws.
Please wait until you are 12 years old to DIY HRT.
Note that your puberty most likely has not ended or reached full development.
So you don't get blockers around this time, don't panic.
Please join our Matrix server to receive HRT support, regardless if it's DIY or not.
Teens in the age range generally need lower dosages of puberty blocker versus those in the 14 years old and over age range.
| Injection Formulation | Oral / Every 24 Hours |
|---|---|
| Relugolix | 20mg |
| Pill Type | Oral / Every 24 Hours |
|---|---|
| Cyproterone | 6.25mg |
| Bicalutamide | 25mg |
| Spironolactone | 100mg |
| Injection Formulation | Oral / Every 24 Hours |
|---|---|
| Relugolix | 40mg |
| Pill Type | Oral / Every 24 Hours |
|---|---|
| Cyproterone | 12.5mg |
| Bicalutamide | 50mg |
| Spironolactone | 200mg |